Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production

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dc.contributor.authorDias A.R.M.
dc.contributor.authorde Miranda B.N.M.
dc.contributor.authorCobas-Gomez H.
dc.contributor.authorPoco J.G.R.
dc.contributor.authorRubio M.R.G.
dc.contributor.authorde Oliveira A.M.
dc.date.accessioned2019-08-20T00:12:01Z
dc.date.available2019-08-20T00:12:01Z
dc.date.issued2019
dc.description.abstract© 2019 Associacao Brasileira de Polimeros. All rights reserved.Poly(ε-caprolactone)-block-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, triblock) and Poly(ε-caprolactone)block-(poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide)-poly (ε-caprolactone) (PCL-PEO-PPO-PEO-PCL, pentablock) copolymers were synthesized by transesterification with reduction of PCL molecular mass, enabling fewer reactions, lower temperatures, and eliminating extensive purification steps. Free hydrophilic groups were removed from the samples by selective precipitation, and 1H-NMR, FTIR, GPC and DSC analyses characterized the structure and properties of the resulting copolymers. The detection of remaining hydrophilic groups indicates the formation of the amphiphilic block copolymers (BCPs). Further, we obtained polymeric nanoparticles with monodisperse size distribution profiles by nano-precipitation from both the triblock and the pentablock copolymers using a microfluidic device, resulting 144.6 and 188.9 nm size and 0.093 and 0.102 nm polydispersity index, respectively. The nanoparticle assembly depends on the copolymer composition, and the possibility of nanoparticle assembly corroborates to the block structure of the copolymers, and the success of this synthesis route to obtain BCPs.
dc.description.firstpage1
dc.description.issuenumber2
dc.description.volume29
dc.identifier.citationDIAS, ANDRÉ ROCHA MONTEIRO; MIRANDA, BEATRIZ NOGUEIRA MESSIAS DE; COBAS-GOMEZ, HOUARI; Poço, João Guilherme Rocha; RUBIO, MARIO RICARDO GONGORA; OLIVEIRA, ADRIANO MARIM DE. Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production. Polímeros: ciência e Tecnologia, v. 29, n. 2, p. 1, 2019.
dc.identifier.doi10.1590/0104-1428.02918
dc.identifier.issn1678-5169
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/1682
dc.relation.ispartofPolimeros
dc.rightsAcesso Aberto
dc.subject.otherlanguageCopolymers
dc.subject.otherlanguagePluronic F127®
dc.subject.otherlanguagePoly(ethylene glycol)
dc.subject.otherlanguagePoly(ε-caprolactone)
dc.subject.otherlanguageTransesterification
dc.titleSynthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production
dc.typeArtigo
fei.scopus.citations1
fei.scopus.eid2-s2.0-85078563894
fei.scopus.subjectAmphiphilic block copolymers
fei.scopus.subjectCaprolactone
fei.scopus.subjectMonodisperse size distribution
fei.scopus.subjectNano-particle production
fei.scopus.subjectPluronic F-127
fei.scopus.subjectPoly (epsiloncaprolactone)
fei.scopus.subjectStructure and properties
fei.scopus.subjectSynthesis and characterizations
fei.scopus.updated2024-03-04
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078563894&origin=inward
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