Preliminary in vitro and ex vivo evaluation of afzelin, kaempferitrin and pterogynoside action over free radicals and reactive oxygen species

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dc.contributor.authorVellosa J.C.R.
dc.contributor.authorRegasini L.O.
dc.contributor.authorBello C.
dc.contributor.authorSchemberger J.A.
dc.contributor.authorKhalil N.M.
dc.contributor.authorDe Araujo Morandim-Giannetti A.
dc.contributor.authorDa Silva Bolzani V.
dc.contributor.authorBrunetti I.L.
dc.contributor.authorDe Faria Oliveira O.M.M.
dc.date.accessioned2019-08-20T00:12:01Z
dc.date.available2019-08-20T00:12:01Z
dc.date.issued2015
dc.description.abstract© 2014 The Pharmaceutical Society of Korea.Biological activities of flavonoids have been extensively reviewed in literature. The biochemical profile of afzelin, kaempferitrin, and pterogynoside acting on reactive oxygen species was investigated in this paper. The flavonoids were able to act as scavengers of the superoxide anion, hypochlorous acid and taurine chloramine. Although flavonoids are naturally occurring substances in plants which antioxidant activities have been widely advertised as beneficial, afzelin, kaempferitrin, and pterogynoside were able to promote cytotoxic effect. In red blood cells this toxicity was enhanced, depending on flavonoids concentration, in the presence of hypochlorous acid, but reduced in the presence of 2,2′-azo-bis(2-amidinopropane) free radical. These flavonoids had also promoted the death of neutrophils, which was exacerbated when the oxidative burst was initiated by phorbol miristate acetate. Therefore, despite their well-known scavenging action toward free radicals and oxidants, these compounds could be very harmful to living organisms through their action over erythrocytes and neutrophils.
dc.description.firstpage1168
dc.description.issuenumber6
dc.description.lastpage1177
dc.description.volume38
dc.identifier.citationVELLOSA, JOSÉ CARLOS REBUGLIO; REGASINI, LUIS OCTÁVIO; BELLÓ, CAROLINE; SCHEMBERGER, JOSIANE APARECIDA; KHALIL, NAJEH MAISSAR; DE ARAÚJO MORANDIM-GIANNETTI, ANDREIA; DA SILVA BOLZANI, VANDERLAN; BRUNETTI, IGUATEMY LOURENÇO; DE FARIA OLIVEIRA, OLGA MARIA MASCARENHAS. Preliminary in vitro and ex vivo evaluation of afzelin, kaempferitrin and pterogynoside action over free radicals and reactive oxygen species. Archives of Pharmacal Research (Seoul. Print), v. 38, p. 1168-1177, 2014.
dc.identifier.doi10.1007/s12272-014-0487-1
dc.identifier.issn1976-3786
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/1685
dc.relation.ispartofArchives of Pharmacal Research
dc.rightsAcesso Restrito
dc.subject.otherlanguageAntioxidants
dc.subject.otherlanguageFlavonoids
dc.subject.otherlanguageFree radicals
dc.subject.otherlanguageOxidative burst
dc.subject.otherlanguagePterogyne nitens
dc.subject.otherlanguageRed blood cells lysis
dc.titlePreliminary in vitro and ex vivo evaluation of afzelin, kaempferitrin and pterogynoside action over free radicals and reactive oxygen species
dc.typeArtigo
fei.scopus.citations22
fei.scopus.eid2-s2.0-84931260899
fei.scopus.subjectAnimals
fei.scopus.subjectCell Death
fei.scopus.subjectErythrocytes
fei.scopus.subjectFabaceae
fei.scopus.subjectFlavonols
fei.scopus.subjectFree Radical Scavengers
fei.scopus.subjectHemolysis
fei.scopus.subjectHumans
fei.scopus.subjectHypochlorous Acid
fei.scopus.subjectIn Vitro Techniques
fei.scopus.subjectKaempferols
fei.scopus.subjectMannosides
fei.scopus.subjectNeutrophils
fei.scopus.subjectOxidative Stress
fei.scopus.subjectProanthocyanidins
fei.scopus.subjectRats
fei.scopus.subjectReactive Oxygen Species
fei.scopus.subjectRespiratory Burst
fei.scopus.subjectSuperoxides
fei.scopus.subjectTaurine
fei.scopus.subjectTetradecanoylphorbol Acetate
fei.scopus.updated2024-05-01
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84931260899&origin=inward
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