Enzymatically obtaining hydrogels of PVA crosslinked with ferulic acid in the presence of laccase for biomedical applications

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dc.contributor.authorBersanetti P.A.
dc.contributor.authorEscobar V.H.
dc.contributor.authorNogueira R.F.
dc.contributor.authorOrtega F.D.S.
dc.contributor.authorSchor P.
dc.contributor.authorMorandim-Giannetti A.D.A.
dc.date.accessioned2019-08-20T00:12:03Z
dc.date.available2019-08-20T00:12:03Z
dc.date.issued2019
dc.description.abstract© 2018 Elsevier Ltd Hydrogels are three-dimensional natural or synthetic polymeric materials with numerous medical and biological applications, such as the ophthalmic area. In this context, a hydrogel using polyvinyl alcohol (PVA) and ferulic acid in the presence of laccase was obtained. The concentrations of PVA, laccase, and ferulic acid were modified, and their effects were analyzed in terms of refractive index, density, and dynamic viscosity. The best condition for obtaining the hydrogel was 12.0% of PVA (w/w), laccase concentration of 836 μg mL −1 , and ferulic acid concentration of 1.95 mM. The rheological measurements confirmed the PVA reticulation with ferulic acid in the presence of laccase, as it promoted an increase in viscosity. On the other hand, the reaction stimulated a decrease in the swelling degree, crystallinity, and melting temperature. Therefore, these results confirm the formation of crosslinks among the PVA chains.
dc.description.firstpage610
dc.description.lastpage618
dc.description.volume112
dc.identifier.citationBERSANETTI, PATRÍCIA ALESSANDRA; ESCOBAR, VICTOR HUGO; NOGUEIRA, REGINA FREITAS; ORTEGA, FERNANDO DOS SANTOS; SCHOR, PAULO; GIANNETTI, Andreia de Araujo Morandim. Enzymatically obtaining hydrogels of PVA crosslinked with ferulic acid in the presence of laccase for biomedical applications. EUROPEAN POLYMER JOURNAL, v. 112, p. 610-618, 2019.
dc.identifier.doi10.1016/j.eurpolymj.2018.10.024
dc.identifier.issn0014-3057
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/1714
dc.relation.ispartofEuropean Polymer Journal
dc.rightsAcesso Restrito
dc.subject.otherlanguageBiomedical applications
dc.subject.otherlanguageEnzymatic crosslinking
dc.subject.otherlanguageHydrogel
dc.subject.otherlanguageLaccase
dc.subject.otherlanguagePolyvinyl alcohol
dc.titleEnzymatically obtaining hydrogels of PVA crosslinked with ferulic acid in the presence of laccase for biomedical applications
dc.typeArtigo
fei.scopus.citations24
fei.scopus.eid2-s2.0-85055747885
fei.scopus.subjectBiological applications
fei.scopus.subjectBiomedical applications
fei.scopus.subjectCrystallinities
fei.scopus.subjectDynamic viscosities
fei.scopus.subjectEnzymatic crosslinking
fei.scopus.subjectLaccases
fei.scopus.subjectPoly (vinyl alcohol) (PVA)
fei.scopus.subjectRheological measurements
fei.scopus.updated2024-03-04
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055747885&origin=inward
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