Direct oxidation of 3-picoline (3-methyl-pyridine) to nicotinic acid with pure HNO3
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2023-07-17
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GOMES, E. L.
FREITAS, D. A. DE
Rodrigo Condotta
João Guilherme Rocha Poço
FREITAS, D. A. DE
Rodrigo Condotta
João Guilherme Rocha Poço
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Brazilian Journal of Chemical Engineering
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GOMES, E. L.; FREITAS, D. A. DE; CONDOTTA, R.; POÇO, J. G. R. Direct oxidation of 3-picoline (3-methyl-pyridine) to nicotinic acid with pure HNO3. Brazilian Journal of Chemical Engineering, july, 2023.
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© 2023, The Author(s) under exclusive licence to Associação Brasileira de Engenharia Química.Nicotinic acid (NA) was synthesized by directly oxidizing 3-methylpyridine (3MP) with nitric acid. The reaction was performed in an instrumented PARR reactor. The effect of temperature (165 to 195 °C) and the molar composition of the initial reactive mixture were studied. Molar conversions of 3-methylpyridine ranged from 36 to 90%, with a yield of NA ranging from 31 to 62%. Better selectivities occur at low-time reactions and low conversion rates. At the same time, the HNO3 excess and temperature considerably affect 3MP conversion rate and NA yield rather than selectivity, especially at 180 °C, whereas an invariable selectivity of 80% was observed.