DSC analysis of the influence of time and concentration of Stryphnodendron adstringens extract on corneal cross-linking

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dc.contributor.authorBERSANETTI, P. A.
dc.contributor.authorMARQUINI, A. A.
dc.contributor.authorAndreia de Araújo Morandim Giannetti
dc.date.accessioned2022-12-01T06:03:22Z
dc.date.available2022-12-01T06:03:22Z
dc.date.issued2022-11-11
dc.description.abstract© 2022, Akadémiai Kiadó, Budapest, Hungary.Keratoconus is an ectasia that leads to reduced stiffness of the cornea, which acquires a conical shape. Many studies are being carried out aiming at new treatments that lead to the recovery of these cross-links. Therefore, the efficiency of the Stryphnodendron adstringens butanolic extract in promoting cross-linking in corneal stroma of porcine eyes was analyzed. The influence of concentration of this plant extract to form cross-links was analyzed, as well as the influence of the contact time. The denaturation temperature results obtained for corneas treated with 1, 2, or 4% of the barbatimão butanolic extract show an increase of 3.84, 11.37, and 33.23%, respectively. These results suggest a rise in the number of cross-links. As for the contact time of the cornea with the 2% solution of the butanolic extract, it appears that the ideal time was 60 min. Enzymatic digestion assays confirm a decrease of 39% and 59% in the relative area and relative mass of corneas in the control group, while for the group treated with the barbatimão extract, these values were close to 0% and 9%, respectively. Therefore, it was possible to verify the efficiency of the barbatimão butanolic extract in modifying the stroma of porcine corneas, which promoted an increase in resistance to thermal and enzymatic degradation.
dc.identifier.citationBERSANETTI, P. A.; MARQUINI, A. A.; GIANNETTI, A. A. M. DSC analysis of the influence of time and concentration of Stryphnodendron adstringens extract on corneal cross-linking. Journal of Thermal Analysis and Calorimetry, Nov. 2022.
dc.identifier.doi10.1007/s10973-022-11730-9
dc.identifier.issn1588-2926
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/4649
dc.relation.ispartofJournal of Thermal Analysis and Calorimetry
dc.rightsAcesso Restrito
dc.subject.otherlanguageCornea
dc.subject.otherlanguageCross-linking
dc.subject.otherlanguageDegradation
dc.subject.otherlanguageDSC
dc.subject.otherlanguageStryphnodendron adstringens
dc.titleDSC analysis of the influence of time and concentration of Stryphnodendron adstringens extract on corneal cross-linking
dc.typeArtigo
fei.scopus.citations0
fei.scopus.eid2-s2.0-85141577428
fei.scopus.subjectContact time
fei.scopus.subjectCornea
fei.scopus.subjectCorneal stroma
fei.scopus.subjectCross linking
fei.scopus.subjectDenaturation temperatures
fei.scopus.subjectDSC
fei.scopus.subjectEnzymatic digestions
fei.scopus.subjectPorcine eye
fei.scopus.subjectReduced stiffness
fei.scopus.subjectStryphnodendron adstringen
fei.scopus.updated2024-05-01
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85141577428&origin=inward
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