Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute

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dc.contributor.authorMorandim-Giannetti A.D.A.
dc.contributor.authorSilva R.C.
dc.contributor.authorMagalhaes O.
dc.contributor.authorSchor P.
dc.contributor.authorBersanetti P.A.
dc.date.accessioned2019-08-20T00:12:01Z
dc.date.available2019-08-20T00:12:01Z
dc.date.issued2016
dc.description.abstract© 2015 Wiley Periodicals, Inc.Hydrogels are polymeric materials with numerous medical and biological applications because of their physicochemical properties. In this context, the conditions were defined for obtaining a hydrogel with characteristics similar to the vitreous humor using polyvinyl alcohol (PVA) and trisodium trimetaphosphate (STMP). The concentration of PVA (X1), PVA/STMP ratio (X2), and initial pH (X3) were modified, and their effect was analyzed in terms of the refractive index (Y1), density (Y2), dynamic viscosity (Y3), and final pH (Y4). The results demonstrated that X1 interferes with Y1, Y2, and Y3, and X2 interferes with Y2 and Y3. The best condition for obtaining a hydrogel with characteristics similar to the vitreous humor was 4.2586% PVA (wt/wt), STMP/PVA ratio of 1:6.8213 (wt/wt), and initial pH of 9.424. DSC, ATR-FTIR, swelling degree, and AFM analysis confirmed the PVA reticulation with STMP. Furthermore, STMP increased the glass transition temperature and decreased the water uptake of ∼50% of the hydrogels, which can be explained by the crosslinking of PVA chains. Infrared spectroscopy revealed a decrease of hydroxyl bonds and confirmed the reticulation between PVA and STMP. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1386–1395, 2016.
dc.description.firstpage1386
dc.description.issuenumber7
dc.description.lastpage1395
dc.description.volume104
dc.identifier.citationGIANNETTI, Andreia de Araujo Morandim; SILVA, ROSIANNE CRISTINA; MAGALHÃES, OCTAVIANO; SCHOR, PAULO; BERSANETTI, PATRÍCIA ALESSANDRA. Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, v. 104, n. 7, p. 1386-1395, 2016.
dc.identifier.doi10.1002/jbm.b.33473
dc.identifier.issn1552-4981
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/1688
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterials
dc.rightsAcesso Restrito
dc.subject.otherlanguagecrosslinking
dc.subject.otherlanguagehydrogel
dc.subject.otherlanguagepolyvinylalcohol
dc.subject.otherlanguagevitreous substitute
dc.titleConditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute
dc.typeArtigo
fei.scopus.citations16
fei.scopus.eid2-s2.0-84991250957
fei.scopus.subjectBiological applications
fei.scopus.subjectDynamic viscosities
fei.scopus.subjectPhysicochemical property
fei.scopus.subjectPoly (vinyl alcohol) (PVA)
fei.scopus.subjectSwelling degree
fei.scopus.subjectVitreous humor
fei.scopus.subjectVitreous substitute
fei.scopus.subjectWater uptake
fei.scopus.updated2024-03-04
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991250957&origin=inward
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