Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test

dc.contributor.authorAndreia de Araújo Morandim Giannetti
dc.contributor.authorCotinguiba F.
dc.contributor.authorREGASINI, L. O.
dc.contributor.authorFRIGIERI, M. C.
dc.contributor.authorVARANDA, E. A.
dc.contributor.authorCOQUEIRO, A.
dc.contributor.authorKATO, M. J.
dc.contributor.authorBOLZANI, V. S.
dc.contributor.authorFURLAN, M.
dc.contributor.authorOrcidhttps://orcid.org/0000-0002-5428-768X
dc.date.accessioned2023-08-26T23:49:33Z
dc.date.available2023-08-26T23:49:33Z
dc.date.issued2011-06-15
dc.description.abstractPhytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (Z)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. © 2011 Academic Journals.
dc.description.firstpage5398
dc.description.issuenumber27
dc.description.lastpage5401
dc.description.volume10
dc.identifier.citationGIANNETTI, A. DE A. M.; CONTINGUIBA, F.; REGASINI, L. O.; FRIGIERI, M. C.; VARANDA, E. A.; COQUEIRO, A. KATO, M. J. BOLZANI, V. S.; FURLAN, M. Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test. African Journal of Biotechnology, v. 27, n. 10, p. 5398-5401, jun. 2011.
dc.identifier.issn1684-5315
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/4980
dc.relation.ispartofAfrican Journal of Biotechnology
dc.rightsAcesso Restrito
dc.subject.otherlanguage(z)-piplartine
dc.subject.otherlanguageAmes test
dc.subject.otherlanguageMutagenic activated
dc.subject.otherlanguagePiper tuberculatum
dc.subject.otherlanguagePiperaceae
dc.titleStudy of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
dc.typeArtigo
fei.scopus.citations6
fei.scopus.eid2-s2.0-79959357732
fei.scopus.updated2024-12-01
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79959357732&origin=inward
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