Biocompatibility of polyvinyl alcohol/trisodium trimetaphosphate as vitreous substitute in experimental vitrectomy model in rabbits

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dc.contributor.advisorOrcidhttps://orcid.org/0000-0002-5428-768X
dc.contributor.authorOLIVEIRA, R. A. DE
dc.contributor.authorMURALHA, F. P.
dc.contributor.authorGRUPENMACHER, A. T.
dc.contributor.authorAndreia de Araújo Morandim Giannetti
dc.contributor.authorBERSANETTI, P. A.
dc.contributor.authorMAIA, M.
dc.contributor.authorMAGALHÃES JUNIOR, O.
dc.date.accessioned2023-06-01T06:06:04Z
dc.date.available2023-06-01T06:06:04Z
dc.date.issued2022-02-05
dc.description.abstract© 2021 Wiley Periodicals LLC.Synthetic hydrogels have been proposed as vitreous substitutes recently. This study aims to evaluate the biocompatibility of polyvinyl alcohol (PVA) crosslinked with trisodium trimetaphosphate (SMTP) hydrogel in rabbit vitrectomized eyes. Seven animals were submitted to pars plana vitrectomy and the vitreous was replaced by PVA/SMTP hydrogel. Optical coherence tomography, fluorescein angiogram, clinical, and electrophysiological (ERG) examinations were analyzed at baseline, on postoperative days 7 and 30. The fellow eye was used as the control group. Hydrogel opacification was observed and ERG recordings were reduced in the hydrogel group in rod response, b-wave cone response and flicker. A histological analysis showed retinal disorganization, presence of multinucleated cells, and intraretinal hydrogel particles. The PVA/SMTP hydrogel showed poor biocompatibility. Novel biomaterials compounds should be analyzed in vivo.
dc.description.firstpage460
dc.description.issuenumber2
dc.description.lastpage466
dc.description.volume110
dc.identifier.citationOLIVEIRA, R. A. DE; MURALHA, F. P.; GRUPENMACHER, A. T.; GIANNETTI, A. DE A. M.; BERSANETTI, P. A.; MAIA, M. Biocompatibility of polyvinyl alcohol/trisodium trimetaphosphate as vitreous substitute in experimental vitrectomy model in rabbits. Journal of Biomedical Materials Research - Part B Applied Biomaterials, v. 110, n. 2, p. 460-466, feb. 2022.
dc.identifier.doi10.1002/jbm.b.34923
dc.identifier.issn1552-4981
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/4802
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterials
dc.rightsAcesso Restrito
dc.subject.otherlanguagebiocompatible materials
dc.subject.otherlanguageelectroretinography
dc.subject.otherlanguagehydrogels
dc.subject.otherlanguagevitreoretinal surgery
dc.subject.otherlanguagevitreous body
dc.titleBiocompatibility of polyvinyl alcohol/trisodium trimetaphosphate as vitreous substitute in experimental vitrectomy model in rabbits
dc.typeArtigo
fei.scopus.citations1
fei.scopus.eid2-s2.0-85111536718
fei.scopus.subjectControl groups
fei.scopus.subjectHistological analysis
fei.scopus.subjectHydrogel particles
fei.scopus.subjectMultinucleated cells
fei.scopus.subjectOpacification
fei.scopus.subjectPoly (vinyl alcohol) (PVA)
fei.scopus.subjectPost-operative days
fei.scopus.subjectVitreous substitute
fei.scopus.subjectAnimals
fei.scopus.subjectHydrogels
fei.scopus.subjectPolyvinyl Alcohol
fei.scopus.subjectRabbits
fei.scopus.subjectRetina
fei.scopus.subjectVitrectomy
fei.scopus.subjectVitreous Body
fei.scopus.updated2024-07-01
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85111536718&origin=inward
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