A New Biomarker for Alzheimer’s Based on the Hippocampus Image Through the Evaluation of the Surface Charge Distribution
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2019-01-05
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BELARDI, A. A.
DE O. FREITAS, F.
BECHELLI, R. P.
PIVA, R. G. G.
DE O. FREITAS, F.
BECHELLI, R. P.
PIVA, R. G. G.
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Advances in Computerized Analysis in Clinical and Medical Imaging
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BELARDI, A. A.; DE O. FREITAS, F.; BECHELLI, R. P.; PIVA, R. G. G. A New Biomarker for Alzheimer’s Based on the Hippocampus Image Through the Evaluation of the Surface Charge Distribution. Advances in Computerized Analysis in Clinical and Medical Imaging, 2019, p. 1-16.
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© 2020 by Taylor & Francis Group, LLC.Alzheimer’s disease causes losses of the gray material and hippocampus is one of the first regions of the brain to be affected. The objective of this chapter is to present the hippocampus surface charge density distribution as a new approach to analyze hippocampal changes due to Alzheimer’s. We have developed a mathematical model using electrostatics equations together with the method of moments and Haar wavelet to build a practical tool in Matlab, able to efficiently calculate the surface charge densities of hippocampus using the hippocampal masks as input images. We tested the tool in 30 volunteers’ hippocampal masks, obtained from Alzheimer’s Disease Neuroimaging Initiative.