DSC characterization of rabbit corneas treated with Stryphnodendron adstringens (Mart.) Coville extracts

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dc.contributor.authorda Cruz L.G.I.
dc.contributor.authorMoraes G.A.
dc.contributor.authorNogueira R.F.
dc.contributor.authorMorandim-Giannetti A.A.
dc.contributor.authorBersanetti P.A.
dc.date.accessioned2019-08-20T00:12:02Z
dc.date.available2019-08-20T00:12:02Z
dc.date.issued2018
dc.description.abstract© 2017, Akadémiai Kiadó, Budapest, Hungary.Keratoconus is an eye ectasia that affects the cornea causing distortion of vision. Corneal crosslinking promoted by riboflavin photo-stimulated at 365 nm is a treatment used successfully to block the keratoconus progression. In this study, we characterize rabbit corneas subjected to enhanced crosslinking using different vegetable extracts prepared from Stryphnodendron adstringens (Mart.) Coville bark by differential scanning calorimetry. The extracts tested in this study were: aqueous, ketonic, ethanolic, ethyl acetate and hydroalcoholic, which revealed high levels of polyphenols, such as proanthocyanidins. The corneas, obtained from the slaughter rabbits, were divided into groups: control (consisting of untreated corneal samples) and S. adstringens, where the samples were subjected to 4% vegetable extracts for 2 h. The DSC profiles of the corneas were obtained in nitrogen atmosphere. The results showed that temperature and enthalpy of denaturation of the corneal samples treated with S. adstringens were higher than the control group. The control group presents temperature and enthalpy values of 59.8 ± 1.1 °C and 24.6 ± 2.7 J g−1, respectively. After crosslinking with ketone extract, the values were 90.1 ± 1.1 °C and 39.9 ± 2.7 J g−1. These results show that S. adstringens is efficient to increment the crosslinking level of the corneas.
dc.description.firstpage621
dc.description.issuenumber1
dc.description.lastpage625
dc.description.volume131
dc.identifier.citationDA CRUZ, LUIZ GUILHERME ITO; MORAES, GABRIELA DE ANDRADE; NOGUEIRA, REGINA FREITAS; GIANNETTI, Andreia de Araujo Morandim; BERSANETTI, PATRÍCIA ALESSANDRA. DSC characterization of rabbit corneas treated with Stryphnodendron adstringens (Mart.) Coville extracts. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 131, p. 621-625, 2017.
dc.identifier.doi10.1007/s10973-017-6096-8
dc.identifier.issn1588-2926
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/1695
dc.relation.ispartofJournal of Thermal Analysis and Calorimetry
dc.rightsAcesso Restrito
dc.subject.otherlanguageCornea
dc.subject.otherlanguageCrosslinking
dc.subject.otherlanguagePolyphenols
dc.subject.otherlanguageStryphnodendron adstringens
dc.titleDSC characterization of rabbit corneas treated with Stryphnodendron adstringens (Mart.) Coville extracts
dc.typeArtigo
fei.scopus.citations5
fei.scopus.eid2-s2.0-85010961148
fei.scopus.subjectControl groups
fei.scopus.subjectCornea
fei.scopus.subjectEthyl acetates
fei.scopus.subjectNitrogen atmospheres
fei.scopus.subjectPolyphenols
fei.scopus.subjectProanthocyanidins
fei.scopus.subjectStryphnodendron adstringens
fei.scopus.subjectVegetable extracts
fei.scopus.updated2024-03-04
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010961148&origin=inward
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