Manufacture of non-thrombogenic polymer surfaces by gamma irradiation to induce simultaneous grafting and heparinization of thin PVC films

Página do item simplificado
dc.contributor.authorPANZARINI, L. C. G. A.
dc.contributor.authorAndreia de Araújo Morandim Giannetti
dc.contributor.authorGUEDES, S. M. L.
dc.contributor.authorOrcidhttps://orcid.org/0000-0002-5428-768X
dc.date.accessioned2022-01-12T21:53:52Z
dc.date.available2022-01-12T21:53:52Z
dc.date.issued2021-07-05
dc.description.abstract© The Author(s) 2021.Investigations regarding alternative methods for producing polymeric materials with hydrophilic properties have increased considerably. In this context, polymeric biomaterials with hemocompatible surface properties have been successfully obtained by grafting hydrophilic monomers onto commercial polymer films by simultaneous irradiation processes. In this study, simultaneous irradiation and grafting were used to produce a copolymer PVC-co-DMAEMA-co-heparin with hemocompatible surface properties. Characterization by FTIR of the graft copolymer indicates that the increase in monomer grafting levels inhibits the bonding sites to heparin. FTIR-PAS analyses of the graft copolymers showed that the highest graft levels were obtained for the irradiated samples containing 45% of monomer. Heparin, however, could only be detected in the irradiated samples containing 30% of DMAEMA. The analysis of the micrographs, on the other hand, showed that increasing the monomer concentration enhances surface roughness of the graft copolymers. Roughness however decreased with heparin addition. It was possible to verify that an excess of surface roughness of the graft copolymers inhibits anticoagulant properties of heparin, triggering thrombus formation. Platelet adhesion, on its turn, was not significantly affected by the presence of heparin when PVC-co-DMAEMA and PVC-co-DMAEMA-co-heparin, obtained from the systems containing 45% of monomer, are compared. The addition of heparin in the systems containing 30% of DMAEMA resulted in fewer thrombogenic surfaces.
dc.description.firstpage283
dc.description.issuenumber4
dc.description.lastpage295
dc.description.volume36
dc.identifier.citationPANZARINI, L. C. G. A.; GIANNETTI, A. A. M.; GUEDES, S. M. L. Manufacture of non-thrombogenic polymer surfaces by gamma irradiation to induce simultaneous grafting and heparinization of thin PVC films. Journal of Bioactive and Compatible Polymers, v. 36, n. 4, p. 283-295, jul. 2021.
dc.identifier.doi10.1177/08839115211030634
dc.identifier.issn1530-8030
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/3569
dc.relation.ispartofJournal of Bioactive and Compatible Polymers
dc.rightsAcesso Restrito
dc.subject.otherlanguageblood compatibility
dc.subject.otherlanguagecopolymer
dc.subject.otherlanguagegamma irradiation
dc.subject.otherlanguageplatelet adhesion
dc.subject.otherlanguagePolyvinylchloride
dc.titleManufacture of non-thrombogenic polymer surfaces by gamma irradiation to induce simultaneous grafting and heparinization of thin PVC films
dc.typeArtigo
fei.scopus.citations1
fei.scopus.eid2-s2.0-85110047939
fei.scopus.subjectAnticoagulant properties
fei.scopus.subjectCommercial polymers
fei.scopus.subjectHydrophilic monomers
fei.scopus.subjectHydrophilic properties
fei.scopus.subjectIrradiated samples
fei.scopus.subjectMonomer concentration
fei.scopus.subjectPolymeric biomaterials
fei.scopus.subjectSimultaneous irradiation
fei.scopus.updated2024-07-01
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85110047939&origin=inward
Arquivos
Coleções
Artigos