Nanocomposites of PLA/ZnO nanofibers for medical applications: Antimicrobial effect, thermal, and mechanical behavior under cyclic stress

Página do item simplificado
dc.contributor.authorNONATO, R.C.
dc.contributor.authorMEI, L.H.I.
dc.contributor.authorBaltus Cornelius Bonse
dc.contributor.authorLEAL, C.V.
dc.contributor.authorLEVY, C.E.
dc.contributor.authorOLIVEIRA, F.A.
dc.contributor.authorDELARMELINA, C.
dc.contributor.authorDUARTE, M.C.T.
dc.contributor.authorMORALES, A.R.
dc.contributor.authorOrcidhttps://orcid.org/0000-0002-2536-5183
dc.date.accessioned2022-03-01T06:04:59Z
dc.date.available2022-03-01T06:04:59Z
dc.date.issued2022-01-18
dc.description.abstractThe application of biodegradable and biocompatible polymer poly(lactic acid) (PLA) in the medical field has been widely studied. In this study, films of neat PLA and PLA containing 1 wt% ZnO nanofibers obtained by electrospinning (PLA/ZnO) were successfully molded by solvent-cast three-dimensional (3D) printing. Mechanical behavior was assessed by conventional dynamic mechanical analysis (DMA) and by adapting the equipment conditions to simulate a mechanical fatigue test at human body temperature—cyclic stress in isotherm at 36.5°C. DMA results showed that for temperatures above 30°C, the storage module of PLA/ZnO was higher when compared to neat PLA, and in the fatigue test, PLA/ZnO withstood more than 3600 cycles while neat PLA failed after an average of 1768 cycles. Differential scanning calorimetry (DSC) tests revealed that cyclic stress did not cause changes in the degree of crystallinity of the PLA. The microdilution and plating methods were applied to bacteria (Staphylococcus aureus, Salmonella, and Escherichia coli) and to yeast (Candida albicans) and revealed the antimicrobial effect of ZnO nanofibers and the PLA/ZnO composite. The antimicrobial activity and fatigue resistance of PLA/ZnO nanocomposites indicate that the material has potential for application in bone implants.
dc.description.firstpage1
dc.description.lastpage9
dc.identifier.doi10.1002/pen.25913
dc.identifier.issn1548-2634
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/4423
dc.relation.ispartofPolymer Engineering and Science
dc.rightsAcesso Restrito
dc.subject.otherlanguage3D printing
dc.subject.otherlanguageAntimicrobial
dc.subject.otherlanguageElectrospinning
dc.subject.otherlanguageNanocomposite
dc.subject.otherlanguagePolylactic acid
dc.subject.otherlanguageThermal properties
dc.titleNanocomposites of PLA/ZnO nanofibers for medical applications: Antimicrobial effect, thermal, and mechanical behavior under cyclic stress
dc.typeArtigo
fei.scopus.citations18
fei.scopus.eid2-s2.0-85124487413
fei.scopus.subject3-D printing
fei.scopus.subject3D-printing
fei.scopus.subjectAnti-microbial effects
fei.scopus.subjectBiocompatible polymer
fei.scopus.subjectCyclic stress
fei.scopus.subjectElectrospinning
fei.scopus.subjectMechanical behavior
fei.scopus.subjectPoly lactic acid
fei.scopus.subjectThermal behaviours
fei.scopus.subjectZnO nanofibers
fei.scopus.updated2024-07-01
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85124487413&origin=inward
Arquivos
Coleções
Artigos