Electrical stimulation enhances early palatal wound healing in mice

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dc.contributor.authorFERREIRA, C. L.
dc.contributor.authorJARDINI, M. A. N.
dc.contributor.authorNUNES, C. M. M.
dc.contributor.authorBERNARDO, D. V.
dc.contributor.authorCASARIN, R. C. V.
dc.contributor.authorGEDRAITE, E. DOS. S.
dc.contributor.authorMATHIAS, M. A.
dc.contributor.authorLIU, F.
dc.contributor.authorMENDONÇA, G
dc.contributor.authorMENDONÇA, B. D. S.
dc.contributor.authorSANTAMARIA, M. P.
dc.date.accessioned2022-01-12T21:54:13Z
dc.date.available2022-01-12T21:54:13Z
dc.date.issued2021-02-05
dc.description.abstract© 2020 Elsevier LtdBackground/objective: Electrical stimulation (ES) has been used to treat chronic wound and other clinical applications, showing favorable results in wound closure. It was hypothesized that ES can present a positive effect on oral mucosa healing. The aim of this study was to investigate the effects of ES during the palatal mucosa early healing process in Swiss mice. Methods: Ninety animals were divided into two groups: Control (C; n = 45), which received Sham ES applications, and Test (ES; n = 45), which received ES (100 μA; 9 kHz; 660 mVpp) once a day for 3 days. A full thickness wound was performed with a 1.5 mm diameter biopsy punch in the hard palate. Histologically, the following parameters were evaluated: palatal wound closure and epithelial and connective wound edge distance (EED and CED). Furthermore, IL-1β, IL-6, IL-10 TNF-α, and VEGF cytokine levels were evaluated by multiplex assay. The percentage of collagen fibers was assessed using the polarization method and the Smad proteins using the immunofluorescence method. Results: Palatal wound closure presented a significant reduction on day 5 in the ES group (p = 0.01). Additionally, both EED and CED were shorter for all time points in the ES group (p < 0.05), and the inflammatory markers IL-6, IL-10, TNF-α, and VEGF were reduced (p < 0.05). There were no differences in collagen fibers and phospho-Smad2 between the groups. Conclusion: ES had a positive effect on early palatal wound closure outcomes, as well as on inflammatory markers.
dc.description.volume122
dc.identifier.citationFERREIRA, C. L.; JARDINI, M. A. N. ; NUNES, C. M. M.; BERNARDO, D. V.; CASARIN, R. C. V. ; GEDRAITE, E. DOS. S. ; MATHIAS, M. A.; LIU, F.; MENDONÇA, G. ; MENDONÇA, B. D. S. ; SANTAMARIA, M. P. Electrical stimulation enhances early palatal wound healing in mice. Archives of Oral Biology, v. 122, 2021.
dc.identifier.doi10.1016/j.archoralbio.2020.105028
dc.identifier.issn1879-1506
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/3587
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Aberto
dc.rights.licenseCreative Commons "Este é um artigo publicado em acesso aberto sob uma licença Creative commons (CC BY 4.0). Fonte: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85098602226&origin=inward. Acesso em: 18 jan. 2023.
dc.subject.otherlanguageElectrical stimulation
dc.subject.otherlanguageGingival recession
dc.subject.otherlanguageHard palate
dc.subject.otherlanguageOral mucosa
dc.subject.otherlanguageRe-epithelialization
dc.subject.otherlanguageWound healing
dc.titleElectrical stimulation enhances early palatal wound healing in mice
dc.typeArtigo
fei.scopus.citations8
fei.scopus.eid2-s2.0-85098602226
fei.scopus.subjectAnimals
fei.scopus.subjectCytokines
fei.scopus.subjectElectric Stimulation
fei.scopus.subjectMice
fei.scopus.subjectMouth Mucosa
fei.scopus.subjectPalate
fei.scopus.subjectWound Healing
fei.scopus.subjectWounds and Injuries
fei.scopus.updated2024-07-01
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85098602226&origin=inward
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