Biomechanical Analysis of Tissue Engineering Construct for Articular Cartilage Restoration—A Pre-clinical Study

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dc.contributor.advisorOrcidhttps://orcid.org/0000-0002-6416-7681
dc.contributor.advisorOrcidhttps://orcid.org/0000-0002-9268-8660
dc.contributor.authorFARIA, R. R. DE
dc.contributor.authorMAIZATO, M. J. S.
dc.contributor.authorCESTARI, I. A.
dc.contributor.authorHERNANDEZ, A. J.
dc.contributor.authorBUENO, D. F.
dc.contributor.authorRoberto Bortolussi
dc.contributor.authorCyro Albuquerque
dc.contributor.authorFERNANDES, T. L.
dc.date.accessioned2023-06-01T06:06:43Z
dc.date.available2023-06-01T06:06:43Z
dc.date.issued2022-04-15
dc.description.abstract© 2022, Springer Nature Switzerland AG.The chondral lesion and osteoarthritis are conditions associated with an economic burden, since if left untreated may cause changes in the biomechanics of the joint and result in several injuries considered highly disabling to the individual. Mesenchymal Stem Cells (MSCs) have the immunomodulatory capacity and paracrine signaling that are useful for tissue bioengineering to treat bone and cartilage injuries. To the best of our knowledge, there is no institution in Brazil studying cartilage biomechanical properties in Good Manufacturing Practice (GMP) technique. Therefore, this study aims to describe biomechanics analysis for cartilage restoration by tissue engineering and cell therapy treatments in a GMP translational large animal model. A controlled experimental study in fourteen Brazilian miniature pigs was performed, using scaffold-free Tissue Engineering Construct (TEC) from dental pulp and synovial MSCs with 6 months follow-up. To compare the cartilage with and without TEC, indentation and maximum compressive tests were performed, as well as Finite Element model to simulate the osteochondral block and characterize its properties. The Young’s Modulus of each sample was determined, and the outcomes of maximum compressive test demonstrated the cartilage integrity. The proposed method was feasible and capable to properly evaluate articular cartilage restoration.
dc.description.firstpage133
dc.description.lastpage137
dc.description.volume83
dc.identifier.citationFARIA, R. R. DE; MAIZATO, M. J. S.; CESTARI, I. A.; HERNANDEZ, A. J.; BUENO, D. F.; BORTOLUSI, R.; ALBUQUERQUE, C.; FERNANDES, T. L. Biomechanical analysis of tissue engineering construct for articular cartilage restoration: a pre-clinical study. IFMBE Proceedings, v. 53, p. 133-137, apr. 2022.
dc.identifier.doi10.1007/978-3-030-70601-2_22
dc.identifier.issn1433-9277
dc.identifier.urihttps://repositorio.fei.edu.br/handle/FEI/4810
dc.relation.ispartofIFMBE Proceedings
dc.rightsAcesso Restrito
dc.subject.otherlanguageArticular cartilage
dc.subject.otherlanguageBiomechanics
dc.subject.otherlanguageCell therapy
dc.subject.otherlanguageIndentation test
dc.subject.otherlanguageMechanical testing
dc.subject.otherlanguageMesenchymal Stem Cells
dc.titleBiomechanical Analysis of Tissue Engineering Construct for Articular Cartilage Restoration—A Pre-clinical Study
dc.typeArtigo de evento
fei.scopus.citations0
fei.scopus.eid2-s2.0-85128956674
fei.scopus.subjectArticular cartilages
fei.scopus.subjectBiomechanical analysis
fei.scopus.subjectCell therapy
fei.scopus.subjectClinical study
fei.scopus.subjectCompressive tests
fei.scopus.subjectGood Manufacturing Practices
fei.scopus.subjectIndentation test
fei.scopus.subjectMesenchymal stem cell
fei.scopus.subjectPre-clinical
fei.scopus.subjectTissues engineerings
fei.scopus.updated2024-05-01
fei.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85128956674&origin=inward
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